Serial Killer Michael Myers is not finished with Laurie Strode, and their rivalry finally comes to an end. But is this the last we see of Myers? Freddie Harris and Nora Winston are reality programmers at DangerTainment, and are planning to send a group of 6 thrill-seeking teenagers into the childhood home of Myers. Cameras are placed all over the house and no one can get out of the house... and then Michael arrives home!

Adam (Tom Hiddleston), an underground musician, reunites with his lover for centuries (Tilda Swinton) after he becomes depressed and tired with the direction human society has taken. Their love is interrupted and tested by her wild and uncontrollable little sister (Mia Wasikowska).

Heidi, a blond rock chick, DJs at a local radio station, and together with the two Hermans (Whitey and Munster) forms part of the "Big H Radio Team." A mysterious wooden box containing a vinyl record arrives for Heidi, a gift of the Lords. She assumes it's a rock band on a mission to spread their word. As Heidi and Whitey play the Lords' record, it starts to play backwards, and Heidi experiences a flashback to a past trauma. Later, Whitey plays the Lords' record, dubbing them the Lords of Salem, and to his surprise, the record plays normally and is a massive hit with his listeners. The arrival of another wooden box from the Lords presents the Big H team with free tickets, posters and records to host a gig in Salem. Soon, Heidi and her cohorts are far from the rock spectacle they're expecting. The original Lords of Salem are returning and they're out for blood.

Deborah Ballin is a controversial middle-aged TV journalist, who is campaigning on air on behalf of a battered woman who murdered her abusive husband, claiming justifiable defense against the so-called victim. But her outspoken views championing women's rights incense one of the studio's cleaning staff, closet homicidal psycho (and misogynist) Colt Hawker whose deep seated despising all all things female occurred from seeing his Mother throwing boiling oil in the face of his abusive Father when he was a small child (and who's M.O. is to photograph victims he stabs as they're spasming to death). So much so that he decides there and then to shut her up...PERMANENTLY! Managing to beat her home, he soon dispatches her maid Francine, before turning his rage onto her as she come home (greeting her in only wearing her jewelry and make-up). Despite the brutal injuries he lashes out on her, she manages to survive and is rushed off to hospital. But undaunted he catches up to her in hospital and...