Drunkboat tells the story of a young teenager, Abe, who manipulates his unsuspecting alcoholic uncle (Malkovich) into buying a boat from a conman (Goodman).
An aging Hollywood star, Joe Scott, lives a life of narcissistic hedonism, observed by his laconic personal assistant, Ophelia. The death of his childhood best friend, Boots, takes our protagonist, and the movie, into an extended flashback to a sea-side town in 1970's Britain. Hollywood star Joe is now a teenage boy in a tentative relationship with a school-girl called Ruth. Further, his mother's friend, Evelyn, is attempting to seduce him. Engulfed by guilt at the unintended, tragic consequences of his subterfuge, he leaves home. The movie then switches back to contemporary Hollywood. Joe confronts his fear and returns to England for a difficult meeting with Ruth, who had gone on to marry Boots and has been a left a poor widow.
David, a college student, is looking for a job. He is hired by Dr. Stoner as a lab assistant for his research and experiments on snakes. David also begins to fall for Stoner's young daughter, Kristina. However, the good doctor has secretly brewed up a serum that can transform any man into a King Cobra snake-and he plans to use it on David.
In a polluted future Venice researchers work to improve the situation. One day, unknown forces start killing them. A team of soldiers and a couple of civilians is sent to investigate. Soon, they encounter strange murderous creatures.