Former lovers Jimmy and Cherie discover that getting over each other isn't as easy as they thought in this sequel to the romantic comedy Love in a Puff.

A hot one-night stand turns into an awkward morning after when GUY and HOLLY get STUCK in a dead-stopped traffic jam. As they begrudgingly get to know each other, we learn of their sexually raucous evening and then they're led to their surprising destiny.

Kevin and Perry are two 15-year-old boys whose desperation to lose their virginity is so great that it inspires a sort of awe. In the rare moments when they're not thinking about girls, Kevin dreams of being a singer, and Perry has ambitions toward becoming a dance music DJ. When Kevin and Perry manage to stop a bank robbery, they're given a sizable cash reward, and they decide to go on a holiday in Ibiza, which is supposedly populated with thousands of beautiful women willing to sleep with anyone. However, after the boys pack plenty of sunscreen and condoms, Kevin's parents announce that they're tagging along. Undeterred, Kevin and Perry make the trip and meet superstar DJ Eyeball Paul , who may or may not listen to their demo tape. The boys also encounter Gemma and Candice, two scruffy teenage girls who are nearly as eager as Kevin and Perry to get horizontal.

While stuck at a wedding in Palm Springs, Nyles (Andy Samberg) meets Sarah (Cristin Milioti), the maid of honor and family black sheep. After he rescues her from a disastrous toast, Sarah becomes drawn to Nyles and his offbeat nihilism. But when their impromptu tryst is thwarted by a surreal interruption, Sarah must join Nyles in embracing the idea that nothing really matters, and they begin wreaking spirited havoc on the wedding celebration.