The morning they return from their White Castle road trip, Harold and Kumar decide to go to Amsterdam because Harold doesn't want to wait ten days to see Maria again. On the plane, Kumar lights up his new bong, the air marshals think it's a bomb, and Harold and Kumar are arrested as terrorists and sent to Guantanamo Bay. Ordered to fellate a guard, they manage to escape, make their way to Florida, and head for Texas to find Kumar's ex-girlfriend's fiancé, the well-connected Colton, and get him to intercede with Washington on their behalf. Kumar still has a thing for Vanessa, the feds are in hot pursuit, and the legal weed of Amsterdam seems a long way away.

In Europe, a group of American college athletes unknowingly board a train that will become one deadly ride.

In 1844, the peace of Feudal Japan is threatened by cruel Lord Naritsugu Matsudaira, who is politically rising and getting closer to his half-brother, the shogun. After the harakiri of the Namiya clan leader, samurai Shinzaemon Shimada is summoned by the shogun's advisor Sir Doi of the Akashi Clan to listen to the tragedy of Makino Uneme, whose son and daughter-in-law have been murdered by Naritsugu. Then Sir Doi shows a woman with arms, legs and tongue severed by Naritsugu and she writes with her forearm a request to Shinza to slaughter Naritsugu and his samurai. Shinza promises to kill Naritsugu and he gathers eleven other samurais and plots a plan to attack Naritsugu in his trip back to the Akashi land. But the cunning samurai Hanbei Kitou that is responsible for the security of his master foresees Shinza's intent. Shinza decides to go with his samurai through the mountain, where they find the hunter Koyata that guides them off the mountain and joins the group. Now the thirteen men...

Lee Kang-hee is an editorialist of a influential newspaper in South Korea. With the power of the press, he makes the congressman Jang Pil-woo to one of the candidates of the next presidential election. That is the result of a secret deal between Lee and Ahn Sang-goo, a political henchman of Jang Pil-woo. But Ahn makes an almost fatal error, when he gets caught pocketing the record on the Jang's slush fund. The prosecutor Woo Jang-hoon is about to investigate and becomes absolutely determined, because the case would help him making big steps in his career. Ahn gets in real trouble, when he gets dropped by Jang and should have been killed, but is able to flee. Now a bitter war starts between one who is lusting for power, the one who wants vengeance and the one who is eager for success.